Hydrochloric Acid → HCID 19775483, compound

HRID 1613284Notes

Reaction equation

HRID 1613284 reaction equation
[CH3:1][N:2]([CH3:24])[CH2:3][C:4]#[C:5][CH2:6][NH:7][C:8](=[O:23])[C:9]([OH:22])([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[ClH:25]>CO>[ClH:25].[CH3:24][N:2]([CH3:1])[CH2:3][C:4]#[C:5][CH2:6][NH:7][C:8](=[O:23])[C:9]([OH:22])([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14931313HCID 14931313, compound

Product 1

HCID 19775483HCID 19775483, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of N-(4-dimethylamino-2-butynyl)-2-hydroxy-2,2-diphenylacetamide (0.35 g) in methanol (5 ml) was added 6.4N methanolic hydrogen chloride (3 ml) and the solution was evaporated in vacuo. The residue was dissolved in chloroform and the solution was evaporated in vacuo. The oily residue was crystallized from a mixture of isopropyl alcohol and ethyl acetate to give N-(4-dimethylamino-2-butynyl)-2-hydroxy-2,2-diphenylacetamide hydrochloride (0.21 g).

Workup

  1. customthe solution was evaporated in vacuo
  2. dissolutionThe residue was dissolved in chloroform
  3. customthe solution was evaporated in vacuo
  4. customThe oily residue was crystallized from a mixture of isopropyl alcohol and ethyl acetate

Sources & evidence

ORD record
ord-b8d655df827140ac8886692eb5137ff0
Source dataset
uspto-grants-1993_03
Patent number
US05192779

Reaction notes

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