反应详情

N-(4-Diethylamino-2-butynyl)-2-chloro-2-cyclohexyl-2-phenylacetamide hydrochloride (100 mg) was dissolved in water (1 ml) and the solution was refluxed for 20 minutes. After being cooled, the solution was made alkaline (pH 10) with saturated sodium bicarbonate aqueous solution and extracted with ethyl acetate. The extract was washed with sodium chloride aqueous solution, dried over sodium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel with a mixture of chloroform and methanol as an eluent to give N-(4-diethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide (74 mg).

1. temperaturethe solution was refluxed for 20 minutes
2. temperatureAfter being cooled
3. extractionextracted with ethyl acetate
4. washThe extract was washed with sodium chloride aqueous solution
5. dry with materialdried over sodium sulfate
6. customevaporated in vacuo
7. customThe residue was purified by column chromatography on silica gel with a mixture of chloroform and methanol as an eluent