反应详情

Heptylamine (39 g; 0.34 mole was added dropwise to 46.6 g (0.59 mole) of pyridine and 43.4 g (0.43 mole) of acetic anhydride over 30 minutes, and the mixture was further stirred for 2 hours. After the reaction, the mixture was concentrated and extracted by adding water and ether. The ethereal layer was washed successively with a saturated aqueous solution of sodium hydrogen carbonate and then a saturated aqueous solution of sodium chloride, and then dried over anhydrous magnesium sulfate and concentrated to give 51 g of the desired compound yield 96 %).

1. customAfter the reaction
2. concentrationthe mixture was concentrated
3. extractionextracted
4. additionby adding water and ether
5. washThe ethereal layer was washed successively with a saturated aqueous solution of sodium hydrogen carbonate
6. dry with materiala saturated aqueous solution of sodium chloride, and then dried over anhydrous magnesium sulfate
7. concentrationconcentrated