Diethyl Ether → HCID 86745598, compound

HRID 1613455Notes

Reaction equation

HRID 1613455 reaction equation
[CH:1]1([NH:4][C:5]2[NH:6][C:7]3[C:12]([CH:13]=2)=[CH:11][CH:10]=[CH:9][CH:8]=3)[CH2:3][CH2:2]1.[CH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][C:15]=1[S:24]([OH:27])(=[O:26])=[O:25].[CH3:28]COCC>>[CH3:28][N:6]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=2[C:13]2[CH2:15][CH2:14][CH2:23][C:5]1=2.[CH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][C:15]=1[S:24]([OH:27])(=[O:26])=[O:25].[CH2:2]1[CH:1]([NH2:4])[CH2:3]1

Participants

4

Reactant 3

HCID 3283Diethyl Ether2×HCID 84202-Naphthalenesulfonic acidHCID 54086927HCID 54086927, compound

Product 1

HCID 86745598HCID 86745598, compound

Procedure

A 0.75 g portion of the cyclopropylaminoindole compound was dissolved in 75 ml Et2O and stirred while a solution of 0.69 g of 2-naphthalene sulfonic acid in 50 ml Et2O was added slowly. A white precipitate formed which was filtered under N2, washed with 2×50 ml Et2O and dried to afford 1.04 g of 4-methyl-1,2,3,4-tetrahydrocyclopent[b]indol-3-cyclopropylamine 2-naphthalene sulfonate.

Workup

  1. additionwas added slowly
  2. customA white precipitate formed which
  3. filtrationwas filtered under N2
  4. washwashed with 2×50 ml Et2O
  5. customdried

Sources & evidence

ORD record
ord-56f26e8d15454450b38b2a149eca496c
Source dataset
uspto-grants-1993_03
Patent number
US05192789

Reaction notes

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