1-(2,6-Diisopropylphenyloxy)-2-propanol → 1-(2,6-Diisopropylcyclohexyloxy)-2-propanol

HRID 1613550Notes

Reaction equation

HRID 1613550 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[O:13][CH2:14][CH:15]([OH:17])[CH3:16])([CH3:3])[CH3:2].C(C1C=CC=CC=1OCC(O)CC)(C)(C)C>[Pd]>[CH:1]([CH:4]1[CH2:9][CH2:8][CH2:7][CH:6]([CH:10]([CH3:11])[CH3:12])[CH:5]1[O:13][CH2:14][CH:15]([OH:17])[CH3:16])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 197740591-(2,6-Diisopropylphenyloxy)-2-propanolHCID 197740621-(2-tert-Butylphenoxy)butan-2-ol

Product 1

HCID 197740581-(2,6-Diisopropylcyclohexyloxy)-2-propanolYield 67%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The synthesis was carried out in the same manner as described in Example 3b, except that 30 g (0.13 mol) of 1-(2,6-diisopropylphenyloxy)-2-propanol were used instead of 50 g (0.23 mol) of 1-(2-tert-butylphenyloxy)-2-butanol and the amount of the same palladium catalyst was increased to 1.5 g. The reaction was carried out for 5 hours and 21 g of 1-(2,6-diisopropylcyclohexyloxy)-2-propanol were obtained in a 67% yield.

Sources & evidence

ORD record
ord-f266ed4dae734b5e8bcecfcfe6c6acbc
Source dataset
uspto-grants-1993_03
Patent number
US05194423

Reaction notes

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