反应详情

A solution of the crude product of Step 1 (36.5 g, 188 mmol) in chloroform (500 ml) was treated over 30 min with phosphorus trichloride (80 g, 580 mmol) at 0°, heated under reflux for 1 h, cooled to room temperature, and poured onto ice (2 Kg). The mixture was basified with sodium hydroxide and the layers separated. The aqueous phase was extracted with chloroform (500 ml).

1. temperatureheated
2. temperatureunder reflux for 1 h
3. additionpoured onto ice (2 Kg)
4. customthe layers separated
5. extractionThe aqueous phase was extracted with chloroform (500 ml)