HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Phenoxybutyric acid → 4-Phenoxybutyryl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Phenoxybutyric acid | HCID 22741 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 4-Phenoxybutyryl chloride | HCID 78819 | — |
Reaction Steps
252.3 g (1.40 mole) of 4-phenoxybutyric acid, 154 ml (2.1 mole) of thionyl chloride and a few drops of dimethylformamide are heated under reflux with exclusion of moisture. After evolution of gas has ceased (about 2 hours), the mixture is fractionated under water pump vacuum. The acid chloride distils at 149°-151° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05194442 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-59f398bb339c4f6fa1a9f06550d65bed |
| Source note | uspto-grants-1993_03 |