反应详情

252.3 g (1.40 mole) of 4-phenoxybutyric acid, 154 ml (2.1 mole) of thionyl chloride and a few drops of dimethylformamide are heated under reflux with exclusion of moisture. After evolution of gas has ceased (about 2 hours), the mixture is fractionated under water pump vacuum. The acid chloride distils at 149°-151° C.

1. temperatureunder reflux with exclusion of moisture
2. custom(about 2 hours)
3. customThe acid chloride distils at 149°-151° C.