反应详情

133 g (0.70 mol) of alpha-morpholino-3-pyridylacetonitrile, 25.7 g (0.07 mol) of tetrabutylammonium iodide, 278 g (3.5 mol) of 50% strength NaOH, 250 ml (2.65 mol) of isopropyl bromide and 300 ml of toluene, as a two-phase system, were heated at 50° C. for 4 hours with thorough mixing. Working up was carried out by adding water, separating the phases and washing the organic phase three times with water. After the solvent had been distilled off, the crude product in the form of an oil was added dropwise to half-concentrated H2SO4 at 60° C. After 2 hours, the mixture was brought to pH 9 with 50% strength NaOH and was extracted with toluene. The organic phase was washed three times with water and the wash solution was extracted 4 times with toluene. The collected toluene extracts were dried over Na2SO4 and filtered and the filtrate was evaporated down. The product was obtained as a dark oil.

1. customseparating the phases
2. washwashing the organic phase three times with water
3. distillationAfter the solvent had been distilled off
4. additionthe crude product in the form of an oil was added dropwise to half-concentrated H2SO4 at 60° C
5. extractionwas extracted with toluene
6. washThe organic phase was washed three times with water
7. extractionthe wash solution was extracted 4 times with toluene
8. dry with materialThe collected toluene extracts were dried over Na2SO4
9. filtrationfiltered
10. customthe filtrate was evaporated down
11. customThe product was obtained as a dark oil