Triethylamine → HCID 19774190, compound

HRID 1613646Notes

Reaction equation

HRID 1613646 reaction equation
C(N(CC)CC)C.[Cl:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[CH:16]([OH:31])[C:17]([C:25]1[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=1)([OH:24])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23].[CH3:32][S:33](Cl)(=[O:35])=[O:34]>C(Cl)Cl>[Cl:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[CH:16]([O:31][S:33]([CH3:32])(=[O:35])=[O:34])[C:17]([C:25]1[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=1)([OH:24])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 19774207HCID 19774207, compound

Product 1

HCID 19774190HCID 19774190, compoundYield 50.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

23.6 ml (177 mmol) of triethylamine were added dropwise to a mixture of 8.5 g (23 mmol) of 1-(2,4-dichlorophenyl)-2-(pyrid-3-yl)-octane-1,2-diol, 2.5 ml (32 mmol) of methanesulfonyl chloride and 100 ml of methylene chloride at about 20° C. Thereafter, the mixture was washed with 30 ml of saturated sodium bicarbonate solution and 30 ml of water and was worked up in a conventional manner to obtain the product. The crude product was purified by chromatography. Yield: 50.6%.

Workup

  1. washThereafter, the mixture was washed with 30 ml of saturated sodium bicarbonate solution and 30 ml of water
  2. customto obtain the product
  3. customThe crude product was purified by chromatography

Sources & evidence

ORD record
ord-d79aaa442d874f77be54a8e0911cf7e4
Source dataset
uspto-grants-1993_03
Patent number
US05194441

Reaction notes

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