Hydrogen Bromide → HCID 135760619, compound

HRID 1613686Notes

Reaction equation

HRID 1613686 reaction equation
C[O:2][C:3]1[C:12]([O:13]C)=[C:11]2[C:6]([CH:7]=[CH:8][N:9]=[CH:10]2)=[CH:5][CH:4]=1.[BrH:15]>C(O)(=O)C>[BrH:15].[OH:2][C:3]1[C:12]([OH:13])=[C:11]2[C:6]([CH:7]=[CH:8][N:9]=[CH:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 1777537,8-Dimethoxyisoquinoline

Product 1

HCID 135760619HCID 135760619, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

7,8-Dimethoxyisoquinoline (3.2 g, 16.9 mmol) in a mixture of 47% HBr (30 ml) and acetic acid (30 ml) was heated under reflux overnight. After cooling the product crystallized out from the reaction mixture as yellow needles. The crystals were collected by filtration to yield 2.5 g (Yield 61%) of the HBr salt. MP 243°-14 245° C.;

Workup

  1. temperaturewas heated
  2. temperatureunder reflux overnight
  3. temperatureAfter cooling the product
  4. customcrystallized out from the reaction mixture as yellow needles
  5. filtrationThe crystals were collected by filtration

Sources & evidence

ORD record
ord-2df434e08a29471fb598933f41b7b09e
Source dataset
uspto-grants-1993_03
Patent number
US05194433

Reaction notes

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