Ibuprofen, (+-)- → β-Methyl-4-(2-methylpropyl)benzeneethanol

HRID 1613712Notes

Reaction equation

[CH3:1][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH:13]([CH3:15])[CH3:14])=[CH:8][CH:7]=1)[C:3](O)=[O:4].[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:14][CH:13]([CH3:15])[CH2:12][C:9]1[CH:8]=[CH:7][C:6]([CH:2]([CH3:1])[CH2:3][OH:4])=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 3672Ibuprofen, (+-)-2×

HCID 21226445Aluminium lithium hydride

Product 1

HCID 595160β-Methyl-4-(2-methylpropyl)benzeneethanol

Procedure

The title compound was prepared by the procedure of Preparation 2 in quantitative yield from α-methyl-4-(2-methylpropyl)benzeneacetic acid which is Ibuprofen® and lithium aluminum hydride.

Sources & evidence

ORD record: ord-d9778174d4ce46b8a9bd90b934753e5e
Source dataset: uspto-grants-1993_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05194446

Reaction notes

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