Clofibric Acid → 2-(4-Chlorophenoxy)-2-methylpropan-1-ol

HRID 1613714Notes

Reaction equation

[CH3:1][C:2]([O:7][C:8]1[CH:9]=[CH:10][C:11]([Cl:14])=[CH:12][CH:13]=1)([C:4](O)=[O:5])[CH3:3].[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([O:7][C:2]([CH3:1])([CH3:3])[CH2:4][OH:5])=[CH:9][CH:10]=1

Participants

Reactant 2

HCID 2797Clofibric Acid

HCID 21226445Aluminium lithium hydride

Product 1

HCID 191086602-(4-Chlorophenoxy)-2-methylpropan-1-ol

Procedure

The title compound was prepared by the procedure of Preparation 2 in quantitative yield from clofibric acid (Aldrich Chem. Co.) and lithium aluminum hydride.

Sources & evidence

ORD record: ord-8348cb1c5a1549bb8d1c2b877f7b966e
Source dataset: uspto-grants-1993_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05194446

Reaction notes

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