Methylamine → HCID 178482385, compound

HRID 1613879Notes

Reaction equation

HRID 1613879 reaction equation
[CH3:1][NH2:2].[NH2:3][CH:4]1[N:9]=[C:8]([Cl:10])[N:7]=[C:6](F)[N:5]1[O:12][CH:13]([F:15])[F:14]>C(OCC)C>[NH2:3][CH:4]1[N:9]=[C:8]([Cl:10])[N:7]=[C:6]([NH:2][CH3:1])[N:5]1[O:12][CH:13]([F:15])[F:14]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 67783290HCID 67783290, compound

Product 1

HCID 178482385HCID 178482385, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
22 °C

Procedure

2.9 g (0.093 mol) of methylamine were passed over the course of 20 minutes into a stirred solution of 10 g (0.047 mol) of 2-amino-4-chlorodifluoromethoxy-6-fluoro-1,3,5-triazine in 150 ml of diethyl ether at 0° C. The mixture was stirred at 0° C. for one hour and at 22° C. overnight. Washing with water, drying and concentration yielded 9.4 g (89.5% of theory) of the title compound of melting point 143° C. (decomposition).

Workup

  1. washWashing with water
  2. customdrying
  3. concentrationconcentration

Sources & evidence

ORD record
ord-3bea72eb285c429884dd2aa0173c1042
Source dataset
uspto-grants-1993_03
Patent number
US05194610

Reaction notes

Loading…