huagongshe.com
HRID1613984

反应详情

EQUATION

反应方程式

HRID 1613984 的结构方程式

REACTANTS

反应物

2
结构：COC1=CC2=CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@]3(O)[C@@]2(C)CC1
HCID10860060

未命名化合物

结构：[C-]#[N+]C(C)P(=O)(OCC)OCC
HCID11745449

未命名化合物

PRODUCTS

生成物

1
结构：[C-]#[N+]C(C)=C1CC[C@H]2[C@@H]3CC=C4C=C(OC)CC[C@]4(C)[C@@]3(O)CC[C@]12C
HCID57047646

未命名化合物

收率 69%

PROCEDURE

实验过程

Using the procedure of Example 27, 3.10 g of 9α-hydroxy-3-methoxyandrosta-3,5-dien-17-one and 8.02 g of diethyl α-isocyanoethylphosphonate were reacted for 5 hours to produce 2.39 g of the title compound as a mixture of 2 diastereomers. Chromatography was performed on silica gel with toluene/acetone 9/1 containing 0,1% triethylamine as eluent.

WORKUP

后处理

  1. customwere reacted for 5 hours