3-Methoxy-9alpha-hydroxyandrosta-3,5-dien-17-one → 20-Isocyano-3-methoxypregna-3,5,17(20)-trien-9alpha-ol

Participants

Reaction Steps

Using the procedure of Example 27, 3.10 g of 9α-hydroxy-3-methoxyandrosta-3,5-dien-17-one and 8.02 g of diethyl α-isocyanoethylphosphonate were reacted for 5 hours to produce 2.39 g of the title compound as a mixture of 2 diastereomers. Chromatography was performed on silica gel with toluene/acetone 9/1 containing 0,1% triethylamine as eluent.

Provenance & Evidence