Hydrochloric Acid → HCID 14037832, compound

HRID 1614011Notes

Reaction equation

HRID 1614011 reaction equation
[CH3:1][C:2]1([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:6]C(=O)N[C:3]1=[O:8].[OH-:17].[Na+].Cl>O>[CH3:1][C@@:2]([C:3]([OH:17])=[O:8])([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[NH2:6]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 2323175-Methyl-5-phenethyl-imidazolidine-2,4-dione

Product 1

HCID 14037832HCID 14037832, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

54.6 g 5-methyl-5-phenethyl-hydantoin (0.25 Mol) are reacted with 30 g sodium hydroxide (0.75 Mol) and 150 ml water for 3.5 hours in an autoclave at an oil bath temperature of 180° C. After cooling, 350 ml H2O are added and the clear, light brown solution adjusted with hydrochloric acid to pH 7.0. The white precipitate is suctioned off, washed with 20 mg H2O and dried in a vacuum drying cabinet at 65° C. The produce is recrystallized twice from water.

Workup

  1. temperatureAfter cooling
  2. washwashed with 20 mg H2O
  3. customdried in a vacuum
  4. customdrying cabinet at 65° C
  5. customThe produce is recrystallized twice from water

Sources & evidence

ORD record
ord-38b360bf92de4233afb148c329c1c645
Source dataset
uspto-grants-1993_03
Patent number
US05194644

Reaction notes

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