3-Chloro-1-propanol → 3-Hydroxypropyl Dimethyl Octadecyl Ammonium Chloride

HRID 1614033Notes

Reaction equation

HRID 1614033 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH3:3].[Cl:22][CH2:23][CH2:24][CH2:25][OH:26]>C(#N)C>[Cl-:22].[OH:26][CH2:25][CH2:24][CH2:23][N+:2]([CH3:1])([CH3:3])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

Participants

4

Reactant 2

HCID 123133-Chloro-1-propanolHCID 15365Dimethyloctadecylamine

Product 1

HCID 867440933-Hydroxypropyl Dimethyl Octadecyl Ammonium ChlorideYield 77.7%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Employing the procedure of EXAMPLE II, 31.3 g of N,N-dimethyloctadecylamine was reacted with 9.0 g of 3-chloropropanol in 100 ml of acetonitrile to provide a crude product which was recrystallized from acetone to give 29.0 g (70%) of white solids. Proton NMR confirmed the desired structure.

Workup

  1. customto provide a crude product which
  2. customwas recrystallized from acetone

Sources & evidence

ORD record
ord-f44109ef95b34965824094fd6946ac42
Source dataset
uspto-grants-1993_03
Patent number
US05194667

Reaction notes

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