Trifluoroacetic acid → HCID 86746645, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve N-(9-phenylfluorenyl)-3(S)-[(diethoxyphosphinyl)acetyl]piperidine-2(R)-carboxylic acid, ethyl ester (1 g) in acetonitrile (7 mL) and water (1 mL). Cool to 0° C. and add, by dropwise addition, trifluoroacetic acid (7 mL). Stir at 0° C. for 1 hour then warm to room temperature over 1 hour. Extract into ethyl acetate (10×100 mL) and evaporate the solvent in vacuo to give the title compound.

Provenance & Evidence