Trifluoroacetic acid → HCID 86746645, compound

HRID 1614048Notes

Reaction equation

HRID 1614048 reaction equation
C1(C2C3C([N:20]4[CH2:25][CH2:24][CH2:23][C@H:22]([C:26](=[O:36])[CH2:27][P:28]([O:33][CH2:34][CH3:35])([O:30][CH2:31][CH3:32])=[O:29])[C@@H:21]4[C:37]([O:39][CH2:40]C)=[O:38])=CC=CC=3C3C2=CC=CC=3)C=CC=CC=1.FC(F)(F)C(O)=O>C(#N)C.O>[CH2:31]([O:30][P:28]([CH2:27][C:26]([C@H:22]1[CH2:23][CH2:24][CH2:25][NH:20][C@H:21]1[C:37]([O:39][CH3:40])=[O:38])=[O:36])([O:33][CH2:34][CH3:35])=[O:29])[CH3:32]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86746646HCID 86746646, compound

Product 1

HCID 86746645HCID 86746645, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Conditions

Temperature
0 °C

Procedure

Dissolve N-(9-phenylfluorenyl)-3(S)-[(diethoxyphosphinyl)acetyl]piperidine-2(R)-carboxylic acid, ethyl ester (1 g) in acetonitrile (7 mL) and water (1 mL). Cool to 0° C. and add, by dropwise addition, trifluoroacetic acid (7 mL). Stir at 0° C. for 1 hour then warm to room temperature over 1 hour. Extract into ethyl acetate (10×100 mL) and evaporate the solvent in vacuo to give the title compound.

Workup

  1. temperaturethen warm to room temperature over 1 hour
  2. extractionExtract into ethyl acetate (10×100 mL)
  3. customevaporate the solvent in vacuo

Sources & evidence

ORD record
ord-47e349c677ad4d1984fc4e840e18a37a
Source dataset
uspto-grants-1993_03
Patent number
US05194430

Reaction notes

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