Trifluoroacetic acid → HCID 178428557, compound

HRID 1614081Notes

Reaction equation

FC(F)(F)C(O)=O.[F:8][CH:9]([F:61])[O:10][N:11]=[C:12]([C:36]1[N:37]=[C:38]([NH:41]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[S:39][CH:40]=1)[C:13]([NH:15][C@@H:16]1[C:34](=[O:35])[N:18]2[C:19]([C:31]([O-:33])=[O:32])=[C:20]([CH2:23][N+:24]3[N:25]([CH3:30])[CH:26]=[CH:27][C:28]=3[CH3:29])[CH2:21][S:22][C@H:17]12)=[O:14]>>[NH2:41][C:38]1[S:39][CH:40]=[C:36]([C:12](=[N:11][O:10][CH:9]([F:8])[F:61])[C:13]([NH:15][C@@H:16]2[C:34](=[O:35])[N:18]3[C:19]([C:31]([O-:33])=[O:32])=[C:20]([CH2:23][N+:24]4[N:25]([CH3:30])[CH:26]=[CH:27][C:28]=4[CH3:29])[CH2:21][S:22][C@H:17]23)=[O:14])[N:37]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 178428556HCID 178428556, compound

Product 1

HCID 178428557HCID 178428557, compound

Procedure

7β-[2-(2-Aminothiazol-4-yl)-2-(difluoromethoxyimino)acetamido]-3-(2,5-dimethyl-1-pyrazolio)methyl-3-cephem-4-carboxylate (syn isomer) was prepared from trifluoroacetic acid salt of 7β-[2-difluoromethoxyimino-2-(2-tritylaminothiazol-4-yl)acetamido]-3-(2,5- dimethyl-1-pyrazolio)methyl-3-cephem-4-carboxylate (syn isomer) according to a similar manner to that of Example 29.

Sources & evidence

ORD record: ord-540d97ed7a4744fa98531c66e9897486
Source dataset: uspto-grants-1993_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05194432

Reaction notes

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