Hydrochloric Acid → HCID 178478920, compound

HRID 1614090Notes

Reaction equation

HRID 1614090 reaction equation
[ClH:1].O.O.[NH2:4][C:5]1[S:6][CH:7]=[C:8]([C:10](=[N:33][O:34][CH:35]([F:37])[F:36])[C:11]([NH:13][C@@H:14]2[C:31](=[O:32])[N:16]3[C:17]([C:28]([O-:30])=[O:29])=[C:18]([CH2:21][N+:22]4[N:23]([CH3:27])[CH:24]=[CH:25][CH:26]=4)[CH2:19][S:20][C@H:15]23)=[O:12])[N:9]=1>O>[ClH:1].[NH2:4][C:5]1[S:6][CH:7]=[C:8]([C:10](=[N:33][O:34][CH:35]([F:36])[F:37])[C:11]([NH:13][C@@H:14]2[C:31](=[O:32])[N:16]3[C:17]([C:28]([O-:30])=[O:29])=[C:18]([CH2:21][N+:22]4[N:23]([CH3:27])[CH:24]=[CH:25][CH:26]=4)[CH2:19][S:20][C@H:15]23)=[O:12])[N:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178480385HCID 178480385, compound

Product 1

HCID 178478920HCID 178478920, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1N-Hydrochloric acid (3.9 ml) was added to a solution of 7β-[2-(2-aminothiazol-4-yl)-2-(difluoromethoxyimino)acetamido]-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate dihydrate (syn isomer) (2 g) in water (50 ml). The resultant aqueous solution was lyophilized to give 7β-[2-(2-aminothiazol-4-yl)-2-(difluoromethoxyimino)acetamido]-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate hydrochloride (syn isomer) (2.1 g).

Sources & evidence

ORD record
ord-8c43de013f864b0cbf345c631ebd45fe
Source dataset
uspto-grants-1993_03
Patent number
US05194432

Reaction notes

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