1,2-Dibromoethane → 4-Iodopyrazole

HRID 1614103Notes

Reaction equation

HRID 1614103 reaction equation
[I:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.Br[CH2:8][CH2:9][Cl:10].BrCCBr>C1(C)C=CC=CC=1>[I:1][C:2]1[CH:3]=[N:4][N:5]([CH2:8][CH2:9][Cl:10])[CH:6]=1.[I:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1

Participants

6

Reactant 3

HCID 78391,2-DibromoethaneHCID 78491-Bromo-2-ChloroethaneHCID 770224-Iodopyrazole

Product 2

HCID 770224-IodopyrazoleHCID 22064205HCID 22064205, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

When an equivalent amount of 4-iodopyrazole is substituted for 1-ethoxycarbonyl-2H-indazolin-3-one and 2-bromochloroethane is substituted for 1,2-dibromoethane in the procedure of Example 19 using toluene as solvent, 2-(4-iodo-1H-pyrazol-1-yl)ethyl chloride is isolated after column chromatography (4-iodopyrazole, Aldrich, 41%, C).

Sources & evidence

ORD record
ord-0525b5dad7154f6380a51e8f9589c1c1
Source dataset
uspto-grants-1993_03
Patent number
USRE034201

Reaction notes

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