Triethylamine → Valine methyl ester

Participants

Reaction Steps

A 3.30 g amount of L-valine methyl ester hydrochloride was suspended in 50 ml of ether, followed by adding thereto 1.89 g of triethyl amine to obtain an ether solution of the L-valine methyl ester. This solution was added to a solution of 0.12 g of the above-mentioned carboxylic acid (2) in 10 ml of THF to obtain the needles. When the second harmonic generating ability of the crystal powder was determined, the intensity was 3 times of that of urea.

Provenance & Evidence