Triethylamine → Valine methyl ester

HRID 1614115Notes

Reaction equation

HRID 1614115 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:10])[C@H:5]([CH:7]([CH3:9])[CH3:8])[NH2:6].C(N(CC)CC)C>CCOCC>[CH3:2][O:3][C:4](=[O:10])[C@H:5]([CH:7]([CH3:9])[CH3:8])[NH2:6]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 111190Methyl valinate hydrochloride

Product 1

HCID 94285Valine methyl ester

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A 3.30 g amount of L-valine methyl ester hydrochloride was suspended in 50 ml of ether, followed by adding thereto 1.89 g of triethyl amine to obtain an ether solution of the L-valine methyl ester. This solution was added to a solution of 0.12 g of the above-mentioned carboxylic acid (2) in 10 ml of THF to obtain the needles. When the second harmonic generating ability of the crystal powder was determined, the intensity was 3 times of that of urea.

Workup

  1. additionby adding

Sources & evidence

ORD record
ord-30f4b265cc8e466a83b8f92140d78440
Source dataset
uspto-grants-1993_03
Patent number
US05196147

Reaction notes

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