Trimethyl phosphite → HCID 19025087, compound

HRID 1614148Notes

Reaction equation

[C:1](Cl)(=[O:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12](Cl)=[O:13].[P:17]([O:22]C)([O:20][CH3:21])[O:18][CH3:19].[P:24]([O-:29])([O:27][CH3:28])[O:25][CH3:26]>>[OH:15][C:1]([P:17]([O:18][CH3:19])(=[O:22])[O:20][CH3:21])([P:17]([O:20][CH3:21])(=[O:22])[O:18][CH3:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([OH:13])([P:17]([O:20][CH3:21])(=[O:22])[O:18][CH3:19])[P:24]([O:27][CH3:28])(=[O:29])[O:25][CH3:26]

Participants

Reactant 3

HCID 8472Trimethyl phosphite

HCID 2733242Dodecanedioyl dichloride

HCID 21884954Dimethylphosphite

Product 1

HCID 19025087HCID 19025087, compound

Conditions

Temperature: 90 °C

Procedure

5.34 g (0.02 mol) 1,12-dodecanedioyl dichloride was added dropwise, with stirring, in a nitrogen atmosphere, to a mixture of 4.96 g (0.04 mol) of trimethyl phosphite and 4.40 g (0.04 mol) of dimethyl phosphite at room temperature. The mixture was stirred for 10 hrs at 90° C. and the reaction mixture was evaporated under reduced pressure. The oily residue (9.8 g) showed a broad signal at δ=22.3 ppm in the 31P nmr spectrum.

Workup

customthe reaction mixture was evaporated under reduced pressure

Sources & evidence

ORD record: ord-243f524648cb4cefafd37da097b2c398
Source dataset: uspto-grants-1993_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05196409

Reaction notes

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