Hydrogen Peroxide → HCID 10086759, compound

HRID 1614159Notes

Reaction equation

HRID 1614159 reaction equation
[CH2:1]([C:5]1[N:9]2[C:10]3[C:15]([N:16]=[CH:17][C:8]2=[N:7][N:6]=1)=[CH:14][C:13]([Cl:18])=[C:12]([Cl:19])[CH:11]=3)[CH2:2][CH2:3][CH3:4].[OH:20]O>CC(O)=O>[CH2:1]([C:5]1[N:9]2[C:10]3[C:15]([NH:16][C:17](=[O:20])[C:8]2=[N:7][N:6]=1)=[CH:14][C:13]([Cl:18])=[C:12]([Cl:19])[CH:11]=3)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 19772995HCID 19772995, compound

Product 1

HCID 10086759HCID 10086759, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

The carbonyl compound was prepared by combining 500 mg (1.7 mmol) of the quinoxaline compound (7) and 16 ml HOAc, and then adding 5 ml of 30% H2O2. The mixture was heated to 60° C. for 16 hours, and then cooled. The product was recovered by filtration and dried at 0.5 mm and 60° C. overnight, yielding 150 mg of 1-n-butyl-7,8-dichloro-1,2,4-triazolo[4,3-a]quinoxalin-4(5H)-one (8).

Workup

  1. temperaturecooled
  2. filtrationThe product was recovered by filtration
  3. customdried at 0.5 mm and 60° C. overnight

Sources & evidence

ORD record
ord-1c546db0dce143ceb97d13c3bf0d95ef
Source dataset
uspto-grants-1993_03
Patent number
US05196421

Reaction notes

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