Hydrochloric Acid → HCID 19020633, compound

HRID 1614174Notes

Reaction equation

HRID 1614174 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[N:11]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:12]=[C:13]3[C:18]=2[CH:17]=[CH:16][C:15]([F:19])=[CH:14]3)[CH2:6][CH2:5]1)(=O)C.[ClH:27]>>[ClH:27].[F:19][C:15]1[CH:16]=[CH:17][C:18]2[C:13]([CH:14]=1)=[N:12][N:11]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:10]=2[CH:7]1[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19020637HCID 19020637, compound

Product 1

HCID 19020633HCID 19020633, compoundYield 25.1%

Procedure

A mixture of 8 parts of 1-acetyl-4-[6-fluoro-2-(phenylmethyl)-2H-indazol-3-yl]-piperidine and 70 parts of a hydrochloric acid solution 6N was stirred for 6 hours at reflux temperature. The reaction mixture was evaporated and the oily residue was crystallized from 2-propanol. The product was filtered off and dried, yielding 2 parts (25.1%) of 6-fluoro-2-(phenylmethyl)-3-(4-piperidinyl)-2H-indazole monohydrochloride; mp. >300° C. (int. 2).

Workup

  1. temperatureat reflux temperature
  2. customThe reaction mixture was evaporated
  3. customthe oily residue was crystallized from 2-propanol
  4. filtrationThe product was filtered off
  5. customdried

Sources & evidence

ORD record
ord-4e3f4f0ad5084bc6871909fd9d9d3790
Source dataset
uspto-grants-1993_03
Patent number
US05196425

Reaction notes

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