Butyl iodide → HCID 19773381, compound

HRID 1614263Notes

Reaction equation

[C:1]([NH:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][CH:9]([N:15]([CH2:19][CH2:20][CH3:21])[CH2:16][CH2:17][CH3:18])[CH2:10]2)(=[O:3])[CH3:2].[CH2:22](I)[CH2:23][CH2:24][CH3:25]>>[C:1]([N:4]([C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][CH:9]([N:15]([CH2:16][CH2:17][CH3:18])[CH2:19][CH2:20][CH3:21])[CH2:10]2)[CH2:22][CH2:23][CH2:24][CH3:25])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 10962Butyl iodide

HCID 14836523HCID 14836523, compound

Product 1

HCID 19773381HCID 19773381, compound

Procedure

Starting from 2.88 g (0.010 mol) of 5-acetylamino-2-di-n-propylamino-tetraline (Example 4.3.4) and 2.2 g (0.012 mol) of n-butyliodide, the title compound is obtained analogously to Example 4.7.1 in the form of a non-crystallising gum in a yield of 2.9 g (87.8% of theory) and with an Rf value of 0.69 (solvent mixture as specified in 4.7.1).

Sources & evidence

ORD record: ord-0b40fa2f274e497d9fd7aa41414b4c2f
Source dataset: uspto-grants-1993_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05196454

Reaction notes

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