Sodium Hydroxide → Sodium alpha-(o-aminophenyl)-p-bromocinnamate

HRID 1614310노트

반응식

HRID 1614310 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[CH:14][C:15]1[CH:20]=[CH:19][C:18]([Br:21])=[CH:17][CH:16]=1)[C:11]([OH:13])=[O:12])([O-])=O.[OH-].[Na+:23]>O>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[CH:14][C:15]1[CH:16]=[CH:17][C:18]([Br:21])=[CH:19][CH:20]=1)[C:11]([O-:13])=[O:12].[Na+:23]

참가 물질

4

반응물 2

HCID 14798Sodium Hydroxide2회HCID 54296204alpha-(2-Nitrophenyl)-p-bromocinnamic acid

생성물 1

HCID 67859211Sodium alpha-(o-aminophenyl)-p-bromocinnamate

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

To a mixture of FeSO4.7H2O (163 g, 0.586 mol) in 180 ml of water was added 720 ml of 2.5N NaOH and the mixture was stirred and heated at 80° C. A solution of cinnamic acid derivative 1 (20.40 g, 0.05859 mol) in 180 ml of 0.5N NaOH was added temperature was increased to 100° C. and maintained for dropwise. After the addition was complete, the 30 min. The mixture was filtered while hot, and the filtrate was allowed to cool gradually to room temperature. The resulting solid was isolated by filtration to yield, after drying in vacuo, 12.1 g (61%) of the title compound as a tan solid which was used in the next reaction without purification.

후처리

  1. temperaturewas increased to 100° C.
  2. temperaturemaintained for dropwise
  3. additionAfter the addition
  4. customthe 30 min
  5. filtrationThe mixture was filtered while hot, and the filtrate
  6. temperatureto cool gradually to room temperature
  7. customThe resulting solid was isolated by filtration
  8. customto yield
  9. dry with materialafter drying in vacuo, 12.1 g (61%) of the title compound as a tan solid which
  10. customwas used in the next reaction without purification

출처 및 근거

ORD 기록
ord-ad1e1912460647ef92cef3ee79a2d3b6
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05196529

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