1-Bromo-2-butanone → HCID 136403366, compound

HRID 1614327Notes

Reaction equation

HRID 1614327 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](=[S:8])[NH2:7])=[CH:4][CH:3]=1.[Br:11][CH2:12][C:13](=O)[CH2:14][CH3:15]>C(O)C>[BrH:11].[CH2:14]([C:13]1[N:7]=[C:6]([C:5]2[CH:9]=[CH:10][C:2]([OH:1])=[CH:3][CH:4]=2)[S:8][CH:12]=1)[CH3:15]

Participants

4

Reactant 2

HCID 131561-Bromo-2-butanoneHCID 27593444-Hydroxythiobenzamide

Product 1

HCID 136403366HCID 136403366, compoundYield 65.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4.6 parts of 4-hydroxybenzothioamide, 4.5 parts of 1-bromo-2-butanone and 79 parts of ethanol was stirred for 5 hours at reflux temperature. After cooling, the precipitate was filtered off and dried in vacuo at 50° C., yielding 5.6 parts (65.2%) of 4-(4-ethyl-2-thiazolyl)phenol hydrobromide (interm. 14).

Workup

  1. temperatureat reflux temperature
  2. temperatureAfter cooling
  3. filtrationthe precipitate was filtered off
  4. customdried in vacuo at 50° C.

Sources & evidence

ORD record
ord-42c3fd3d557845f3bf59e66b27ee251b
Source dataset
uspto-grants-1993_03
Patent number
US05196535

Reaction notes

Loading…