Hydrochloric Acid → HCID 19773546, compound

HRID 1614330Notes

Reaction equation

HRID 1614330 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]1[CH2:10][CH:9]2[N:11](C(OCC)=O)[CH:6]([CH2:7][CH2:8]2)[CH2:5]1.Cl>>[CH:9]12[NH:11][CH:6]([CH2:7][CH2:8]1)[CH2:5][CH:4]([CH2:3][CH2:2][OH:1])[CH2:10]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19748293HCID 19748293, compound

Product 1

HCID 19773546HCID 19773546, compoundYield 99.6%

Procedure

A mixture of 7.5 parts of ethyl 3-(2-hydroxyethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate (prepared as in EP-A-0,320,032) and 127 parts of hydrochloric acid was refluxed for 1/2 hour and was then evaporated. The residue was taken up in water and the whole was basified with NaOH. The product was extracted with trichloromethane and the extract was washed, dried, filtered and evaporated, yielding 5.1 parts (99.6%) of 8-azabicyclo[3.2.1]octane-3-ethanol (interm. 40).

Workup

  1. temperaturewas refluxed for 1/2 hour
  2. customwas then evaporated
  3. extractionThe product was extracted with trichloromethane
  4. washthe extract was washed
  5. customdried
  6. filtrationfiltered
  7. customevaporated

Sources & evidence

ORD record
ord-f7c7029e8b68457f9b98ab1c44d427f7
Source dataset
uspto-grants-1993_03
Patent number
US05196535

Reaction notes

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