Water → HCID 19773825, compound

HRID 1614416Notes

Reaction equation

HRID 1614416 reaction equation
[F:1][C:2]1[C:9]([F:10])=[CH:8][C:7]([C:11]([F:14])([F:13])[F:12])=[CH:6][C:3]=1[C:4]#N.[OH-:15].[Na+].[OH2:17]>>[F:1][C:2]1[C:9]([F:10])=[CH:8][C:7]([C:11]([F:14])([F:13])[F:12])=[CH:6][C:3]=1[C:4]([OH:17])=[O:15]

Participants

4

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 190908472,3-Difluoro-5-(trifluoromethyl)benzonitrile

Product 1

HCID 19773825HCID 19773825, compound

Conditions

Temperature
97 °C

Procedure

2,3-Difluoro-5-(trifluoromethyl)benzonitrile (60.03 g, 0.29 moles) is added to a solution of 17.5 g (0.43 moles) of sodium hydroxide in 158 ml of water. The mixture is heated to 97° C. during 1 hour and then heating is continued for an additional 2 hours. The mixture is acidified and the solid acid filtered off and air dried to yield 2,3-difluoro-5-(trifluoromethyl)benzoic acid, m.p. 94°-96° C.

Workup

  1. temperatureheating
  2. filtrationthe solid acid filtered off
  3. customair dried

Sources & evidence

ORD record
ord-1b2cceb66a7242cca6461361e0ade2d9
Source dataset
uspto-grants-1993_03
Patent number
US05196593

Reaction notes

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