Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,3-Difluoro-5-(trifluoromethyl)benzonitrile | HCID 19090847 | — |
| Product | HCID 19773825 | HCID 19773825 | — |
Reaction Steps
2,3-Difluoro-5-(trifluoromethyl)benzonitrile (60.03 g, 0.29 moles) is added to a solution of 17.5 g (0.43 moles) of sodium hydroxide in 158 ml of water. The mixture is heated to 97° C. during 1 hour and then heating is continued for an additional 2 hours. The mixture is acidified and the solid acid filtered off and air dried to yield 2,3-difluoro-5-(trifluoromethyl)benzoic acid, m.p. 94°-96° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05196593 |
|---|
| Source dataset | uspto-grants-1993_03 |
|---|
| ORD ID | ord-1b2cceb66a7242cca6461361e0ade2d9 |
|---|
| Source note | uspto-grants-1993_03 |
|---|
