反应详情

温度

0 °C

A suspension of 5-bromo-1,2-dihydro-2,2-dimethyl-6-(2-imidazolin-2-ylamino)-3-(4H)-quinoxalinone (150 mg, 0.45 mmol) and LiALH4 (17 mg, 0.45 mmol) in tetrahydrofuran (3 ml) is heated and maintained at a temperature of 50°-80° C. until the starting material is consumed. The mixture is cooled to 0° C., 2-3 drops of H2O is added and the mixture is filtered. The solution is concentrated in vacuo to yield a residue which is chromatographed on silica gel with CHCl3 : CH3OH saturated with NH3 (g) elution to produce the title compound.

1. temperatureis heated
2. temperaturemaintained at a temperature of 50°-80° C. until the starting material
3. customis consumed
4. addition2-3 drops of H2O is added
5. filtrationthe mixture is filtered
6. concentrationThe solution is concentrated in vacuo
7. customto yield a residue which
8. customis chromatographed on silica gel with CHCl3
9. washCH3OH saturated with NH3 (g) elution