2-Aminopyrimidine → HCID 19772040, compound

HRID 1614646Notes

Reaction equation

HRID 1614646 reaction equation
Cl[CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([CH:11]([C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[NH:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH2:7][CH2:6]1.[NH2:27][C:28]1[N:33]=[CH:32][CH:31]=[CH:30][N:29]=1.C(=O)(O)[O-].[Na+]>C(O)CCC>[F:26][C:23]1[CH:24]=[CH:25][C:20]([CH:11]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:8]2[CH2:9][CH2:10][N:5]([CH2:4][CH2:3][CH2:2][NH:27][C:28]3[N:33]=[CH:32][CH:31]=[CH:30][N:29]=3)[CH2:6][CH2:7]2)=[CH:21][CH:22]=1

Participants

5

Reactant 3

HCID 79782-AminopyrimidineHCID 516892Sodium BicarbonateHCID 19772068HCID 19772068, compound

Product 1

HCID 19772040HCID 19772040, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of equivalent amounts of 1-(3-chloropropyl)-N,α-bis(4-fluorophenyl)-4-piperidinemethanamine, 2-aminopyrimidine, and sodium bicarbonate in 1-butanol is heated at reflux temperature until the reaction is complete. The solvent is removed and the residual material partitioned between water and methylene chloride. The methylene chloride layer is dried and concentrated to obtain the title compound.

Workup

  1. temperatureis heated
  2. temperatureat reflux temperature until the reaction
  3. customThe solvent is removed
  4. customthe residual material partitioned between water and methylene chloride
  5. dry with materialThe methylene chloride layer is dried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-d23d41ec33ac40f59b978c2a8da18b46
Source dataset
uspto-grants-1993_03
Patent number
US05198449

Reaction notes

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