Aniline → HCID 19772096, compound

HRID 1614647Notes

Reaction equation

HRID 1614647 reaction equation
Cl[CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([CH:11]([C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[NH:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH2:7][CH2:6]1.[NH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[F:19][C:16]1[CH:17]=[CH:18][C:13]([NH:12][CH:11]([C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[CH:8]2[CH2:9][CH2:10][N:5]([CH2:4][CH2:3][CH2:2][NH:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:6][CH2:7]2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 6115AnilineHCID 19772068HCID 19772068, compound

Product 1

HCID 19772096HCID 19772096, compound

Procedure

1-(3-Chloropropyl)-N,α-bis(4-fluorophenyl)-4-piperidinemethanamine and excess aniline are heated together until the reaction is complete. Excess aniline is distilled off and the residual material partitioned between dilute aqueous sodium hydroxide and methylene chloride. The methylene chloride solution is dried and concentrated to obtain the title compound.

Workup

  1. distillationExcess aniline is distilled off
  2. customthe residual material partitioned between dilute aqueous sodium hydroxide and methylene chloride
  3. dry with materialThe methylene chloride solution is dried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-bc677eb7c087400fa846399434db0276
Source dataset
uspto-grants-1993_03
Patent number
US05198449

Reaction notes

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