4-[[(3,4-Difluorophenyl)amino](4-fluorophenyl)methyl]piperidine → 1-[3-[(4-Chlorophenyl)sulfinyl]propyl]-N-(3,4-difluorophenyl)-alpha-(4-fluorophenyl)-4-piperidinemethanamine

HRID 1614650Notes

Reaction equation

HRID 1614650 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:10][CH2:11][CH2:12]Cl)=[O:9])=[CH:4][CH:3]=1.[F:14][C:15]1[CH:16]=[C:17]([NH:22][CH:23]([C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)[CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:18]=[CH:19][C:20]=1[F:21]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:10][CH2:11][CH2:12][N:27]2[CH2:28][CH2:29][CH:24]([CH:23]([C:30]3[CH:31]=[CH:32][C:33]([F:36])=[CH:34][CH:35]=3)[NH:22][C:17]3[CH:18]=[CH:19][C:20]([F:21])=[C:15]([F:14])[CH:16]=3)[CH2:25][CH2:26]2)=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 197720314-[[(3,4-Difluorophenyl)amino](4-fluorophenyl)methyl]piperidineHCID 197720711-(p-Chlorophenylsulfinyl)-3-chloropropane

Product 1

HCID 197719671-[3-[(4-Chlorophenyl)sulfinyl]propyl]-N-(3,4-difluorophenyl)-alpha-(4-fluorophenyl)-4-piperidinemethanamine

Procedure

Following the procedure of Example 2, the title compound is prepared from 1-chloro-4-[(3-chloropropyl)sulfinyl]benzene and N-(3,4-difluorophenyl)-α-(4-fluorophenyl)-4-piperidinemethanamine.

Sources & evidence

ORD record
ord-e6ce045b5d9a476c89f5a5a86e9a29c8
Source dataset
uspto-grants-1993_03
Patent number
US05198449

Reaction notes

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