1-Chloro-4-[(3-chloropropyl)sulfonyl]benzene → 1-[3-[(4-Chlorophenyl)sulfonyl]propyl]-N-(3,4-difluorophenyl)-alpha-(4-fluorophenyl)-4-piperidinemethanamine

HRID 1614651Notes

Reaction equation

HRID 1614651 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH2:12][CH2:13]Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[F:15][C:16]1[CH:17]=[C:18]([NH:23][CH:24]([C:31]2[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=2)[CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:19]=[CH:20][C:21]=1[F:22]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH2:12][CH2:13][N:28]2[CH2:29][CH2:30][CH:25]([CH:24]([C:31]3[CH:32]=[CH:33][C:34]([F:37])=[CH:35][CH:36]=3)[NH:23][C:18]3[CH:19]=[CH:20][C:21]([F:22])=[C:16]([F:15])[CH:17]=3)[CH2:26][CH2:27]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 167842621-Chloro-4-[(3-chloropropyl)sulfonyl]benzeneHCID 197720314-[[(3,4-Difluorophenyl)amino](4-fluorophenyl)methyl]piperidine

Product 1

HCID 197720271-[3-[(4-Chlorophenyl)sulfonyl]propyl]-N-(3,4-difluorophenyl)-alpha-(4-fluorophenyl)-4-piperidinemethanamine

Procedure

Following the procedure of Example 2, the title compound is prepared from 1-chloro-4-[(3-chloropropyl)sulfonyl]benzene and N-(3,4-difluorophenyl)-α-(4-fluorophenyl)-4-piperidinemethanamine.

Sources & evidence

ORD record
ord-f013fc28722b4f88b720bcc8f93e863a
Source dataset
uspto-grants-1993_03
Patent number
US05198449

Reaction notes

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