反应详情

1-(2-Methylphenyl)-1-phenyl-1-propanol (10.4 g, 46 mmol) was dissolved into isopropanol (100 ml) and a 4 N sulphuric acid solution (50 ml) was added. The reaction mixture was heated at reflux temperature for 18 h and cooled to room temperature. Water (300 ml) was added and the mixture was extracted with dichloromethane (2×200 ml). The combined organic extracts was washed with a diluted sodium bicarbonate solution, dried over sodium sulphate and the solvent evaporated in vacuo to give 9.0 g (91% of 1-(2-methylphenyl)-1-phenyl-1-propene.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux temperature for 18 h
3. extractionthe mixture was extracted with dichloromethane (2×200 ml)
4. washThe combined organic extracts was washed with a diluted sodium bicarbonate solution
5. dry with materialdried over sodium sulphate
6. customthe solvent evaporated in vacuo