Phosphate → HCID 178512862, compound

HRID 1614846Notes

Reaction equation

HRID 1614846 reaction equation
P([O-])([O-])([O-])=O.CC(O)=O.[CH:10]1[CH:11]=[CH:12][C:13]([CH2:16][C@@H:17]2[NH:41][C:39](=[O:40])[C@H:38]([CH2:42][C:43]3[CH:44]=[CH:45][C:46]([OH:49])=[CH:47][CH:48]=3)[NH:37][C:35](=[O:36])[CH2:34][CH2:33][S:32][S:31][CH2:30][C@@H:29]([C:50]([N:52]3[C@H:56]([C:57]([NH:59][C@@H:60]([C:68]([NH:70][CH2:71][C:72]([NH2:74])=[O:73])=[O:69])[CH2:61][CH2:62][CH2:63][NH:64][C:65]([NH2:67])=[NH:66])=[O:58])[CH2:55][CH2:54][CH2:53]3)=[O:51])[NH:28][C:26](=[O:27])[C@H:25]([CH2:75][C:76]([NH2:78])=[O:77])[NH:24][C:22](=[O:23])[C@H:21]([CH2:79][CH2:80][C:81]([NH2:83])=[O:82])[NH:20][C:18]2=[O:19])=[CH:14][CH:15]=1>Cl>[CH:10]1[CH:15]=[CH:14][C:13]([CH2:16][C@@H:17]2[NH:41][C:39](=[O:40])[C@H:38]([CH2:42][C:43]3[CH:44]=[CH:45][C:46]([OH:49])=[CH:47][CH:48]=3)[NH:37][C:35](=[O:36])[CH2:34][CH2:33][S:32][S:31][CH2:30][C@@H:29]([C:50]([N:52]3[C@H:56]([C:57]([NH:59][C@@H:60]([C:68]([NH:70][CH2:71][C:72]([NH2:74])=[O:73])=[O:69])[CH2:61][CH2:62][CH2:63][NH:64][C:65]([NH2:67])=[NH:66])=[O:58])[CH2:55][CH2:54][CH2:53]3)=[O:51])[NH:28][C:26](=[O:27])[C@H:25]([CH2:75][C:76]([NH2:78])=[O:77])[NH:24][C:22](=[O:23])[C@H:21]([CH2:79][CH2:80][C:81]([NH2:83])=[O:82])[NH:20][C:18]2=[O:19])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 1061PhosphateHCID 178476719HCID 178476719, compound

Product 1

HCID 178512862HCID 178512862, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Dissolution tests of pellets have been carried out according to USP apparatus 2 at 37° C., paddle speed 100 rpm, phosphate buffer pH 6.0, n=6, 1 g per vessel according to about 1400-2100 μg desmopressin acetate. Additionally the enteric pellets were treated 2 h in Hydrochloric acid, 0.1N, before switching at pH 6.0.

Workup

  1. dissolutionDissolution tests of pellets
  2. customhave been carried out according to USP apparatus 2 at 37° C.

Sources & evidence

ORD record
ord-18e93aaaba5442d19bf07955f73473f8
Source dataset
uspto-grants-2014_07
Patent number
US08765152B2

Reaction notes

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