反应详情

温度

0 °C

To a solution of tert-butyl 3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]-3-hydroxyazetidine-1-carboxylate (0.88 g) prepared in (2) in ethyl acetate (4.0 mL) was added a solution of 4 N HCl/ethyl acetate (4.0 mL) at 0° C. The reaction mixture was stirred at 0° C. for 3 hr. Ethyl acetate was added to the reaction mixture. The precipitated solid was collected on a filter and dried to give the title compound (0.53 g, 71%).

1. customThe precipitated solid was collected on
2. filtrationa filter
3. customdried