Dimethylformamide → HCID 59634109, compound

Participants

Reaction Steps

To a solution of 3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]-azetidin-3-ol hydrochloride (0.50 g) prepared in (3), 2-pyridinecalboxylic acid (0.070 g), WSC.HCl (0.12 g) and HOBt.H2O (0.092 g) in DMF (3.0 mL) was added triethylamine (0.070 mL). The reaction mixture was stirred at RT for 15 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was dried over MgSO4. The solvent was removed under reduced pressure. A mixed solvent of chloroform/hexane was added the residue. The precipitated solid was collected on a filter and dried to give the title compound (0.15 g, 74%).

Provenance & Evidence