反应详情

To a solution of 3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]-azetidin-3-ol hydrochloride (0.50 g) prepared in (3), 2-pyridinecalboxylic acid (0.070 g), WSC.HCl (0.12 g) and HOBt.H2O (0.092 g) in DMF (3.0 mL) was added triethylamine (0.070 mL). The reaction mixture was stirred at RT for 15 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was dried over MgSO4. The solvent was removed under reduced pressure. A mixed solvent of chloroform/hexane was added the residue. The precipitated solid was collected on a filter and dried to give the title compound (0.15 g, 74%).

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialThe organic layer was dried over MgSO4
3. customThe solvent was removed under reduced pressure
4. additionA mixed solvent of chloroform/hexane was added the residue
5. customThe precipitated solid was collected on
6. filtrationa filter
7. customdried