HCID 86670913, compound → HCID 86670912, compound

HRID 1615089Notes

Reaction equation

HRID 1615089 reaction equation
[OH2:1].O.O.O.O.[Cl-:6].[CH3:7][C:8]1[SH+:9][CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1>C(#N)C>[OH2:1].[OH2:1].[Cl-:6].[CH3:7][C:8]1[SH+:9][CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 1

HCID 86670913HCID 86670913, compound

Product 1

HCID 86670912HCID 86670912, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2 g of methylthioninium chloride pentahydrate Form A was suspended in 10 ml acetonitrile and stirred at room temperature for 6 days. The solid was filtered off and dried in vacuo at 1 mbar and at room temperature for 15 minutes. This procedure was repeated two times. Pure methylthioninium chloride dihydrate Form C was obtained as greenish crystal powder. The PXRD corresponds to that of example B1. Thermogravimetry revealed a mass loss of 9.8% in two steps between room temperature and 150° C. The total mass loss corresponds almost exactly to a water content of 2 equivalents.

Workup

  1. filtrationThe solid was filtered off
  2. customdried in vacuo at 1 mbar and at room temperature for 15 minutes

Sources & evidence

ORD record
ord-9c32631dddf44388922a80a3fb71addd
Source dataset
uspto-grants-2014_07
Patent number
US08765742B2

Reaction notes

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