HCID 86670913, compound → HCID 86670912, compound

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Reaction Steps

2 g of methylthioninium chloride pentahydrate Form A was suspended in 10 ml acetonitrile and stirred at room temperature for 6 days. The solid was filtered off and dried in vacuo at 1 mbar and at room temperature for 15 minutes. This procedure was repeated two times. Pure methylthioninium chloride dihydrate Form C was obtained as greenish crystal powder. The PXRD corresponds to that of example B1. Thermogravimetry revealed a mass loss of 9.8% in two steps between room temperature and 150° C. The total mass loss corresponds almost exactly to a water content of 2 equivalents.

Provenance & Evidence