HCID 40985380, compound → HCID 67996586, compound

HRID 1615134Notes

Reaction equation

HRID 1615134 reaction equation
[OH:1][C:2]1([CH2:15][CH:16]=O)[CH2:14][CH2:13][C:5]2([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]2)[CH2:4][CH2:3]1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C@@H:25]([NH2:28])[CH2:26][CH3:27])=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([C@@H:25]([NH:28][CH2:16][CH2:15][C:2]2([OH:1])[CH2:14][CH2:13][C:5]3([O:6][CH2:7][C:8]([CH3:12])([CH3:11])[CH2:9][O:10]3)[CH2:4][CH2:3]2)[CH2:26][CH3:27])=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 40985380HCID 40985380, compoundHCID 86668369(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde

Product 1

HCID 67996586HCID 67996586, compoundYield 60%

Procedure

The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-1-(4-chloro-phenyl)-propylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 60% of theory; LC (method 5): tR=1.15 min; Mass spectrum (ESI+): m/z=396/398 (Cl) [M+H]+.

Sources & evidence

ORD record
ord-f91274f618b741a0ba85312e542c967c
Source dataset
uspto-grants-2014_07
Patent number
US08765744B2

Reaction notes

Loading…