HCID 2496556, compound → HCID 67996053, compound

HRID 1615143Notes

Reaction equation

HRID 1615143 reaction equation
[OH:1][C:2]1([CH2:15][CH:16]=O)[CH2:14][CH2:13][C:5]2([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]2)[CH2:4][CH2:3]1.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([C@@H:26]([NH2:29])[CH2:27][CH3:28])=[CH:22][CH:21]=1>>[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([C@@H:26]([NH:29][CH2:16][CH2:15][C:2]2([OH:1])[CH2:3][CH2:4][C:5]3([O:10][CH2:9][C:8]([CH3:11])([CH3:12])[CH2:7][O:6]3)[CH2:13][CH2:14]2)[CH2:27][CH3:28])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 2496556HCID 2496556, compoundHCID 86668369(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde

Product 1

HCID 67996053HCID 67996053, compoundYield 53%

Procedure

The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-1-(4-methoxy-phenyl)-propylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 53% of theory; LC (method 5): tR=1.02 min; Mass spectrum (ESI+): m/z=392 [M+H]+.

Sources & evidence

ORD record
ord-22a0121c75564533b401982799127ad9
Source dataset
uspto-grants-2014_07
Patent number
US08765744B2

Reaction notes

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