HCID 7028357, compound → HCID 67996043, compound

HRID 1615150Notes

Reaction equation

HRID 1615150 reaction equation
[OH:1][C:2]1([CH2:15][CH:16]=O)[CH2:14][CH2:13][C:5]2([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]2)[CH2:4][CH2:3]1.[C:18]1([CH3:28])[CH:23]=[CH:22][C:21]([C@@H:24]([NH2:27])[CH2:25][CH3:26])=[CH:20][CH:19]=1>>[CH3:12][C:8]1([CH3:11])[CH2:7][O:6][C:5]2([CH2:13][CH2:14][C:2]([CH2:15][CH2:16][NH:27][C@H:24]([C:21]3[CH:20]=[CH:19][C:18]([CH3:28])=[CH:23][CH:22]=3)[CH2:25][CH3:26])([OH:1])[CH2:3][CH2:4]2)[O:10][CH2:9]1

Participants

3

Reactant 2

HCID 7028357HCID 7028357, compoundHCID 86668369(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde

Product 1

HCID 67996043HCID 67996043, compoundYield 55%

Procedure

The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-1-p-tolyl-propylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 55% of theory; LC (method 5): tR=1.10 min; Mass spectrum (ESI+): m/z=376 [M+H]+.

Sources & evidence

ORD record
ord-37eecf962bba497ea176b8835916a2b5
Source dataset
uspto-grants-2014_07
Patent number
US08765744B2

Reaction notes

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