1-(4-Bromophenyl)cyclopropanamine → HCID 67996011, compound

HRID 1615151Notes

Reaction equation

HRID 1615151 reaction equation
[OH:1][C:2]1([CH2:15][CH:16]=O)[CH2:14][CH2:13][C:5]2([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]2)[CH2:4][CH2:3]1.[Br:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2([NH2:28])[CH2:27][CH2:26]2)=[CH:21][CH:20]=1>>[Br:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2([NH:28][CH2:16][CH2:15][C:2]3([OH:1])[CH2:3][CH2:4][C:5]4([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]4)[CH2:13][CH2:14]3)[CH2:26][CH2:27]2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 187101951-(4-Bromophenyl)cyclopropanamineHCID 86668369(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde

Product 1

HCID 67996011HCID 67996011, compoundYield 42%

Procedure

The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and 1-(4-bromo-phenyl)-cyclopropylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 42% of theory; LC (method 5): tR=1.12 min; Mass spectrum (ESI+): m/z=438/440 (Br) [M+H]+.

Sources & evidence

ORD record
ord-aeb97e45373d464db0628c7a2e963909
Source dataset
uspto-grants-2014_07
Patent number
US08765744B2

Reaction notes

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